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UID:c7a20b75bd5c1aa5a8aa14ed413f2576
CATEGORIES:Mathematical Physics Seminar
CREATED:20220221T120236
SUMMARY:Phase separation in biological cells
LOCATION:Zoom
DESCRIPTION:Abstract: An emerging mechanism for intracellular organization is biomolecu
 lar phase separation into condensates of proteins and nucleic acids. Howeve
 r, the physical processes that govern the distribution of condensate sizes 
 remain unclear. We utilize a combination of experimental synthetic and nati
 ve condensates and simulations to probe the underlying coarsening mechanism
 s determining condensate size. Distributions range from exponential to powe
 r-law, reflecting the relative rates of nucleation and coalescence kinetics
 . We succinctly account for these differences by indentifying a “rich get r
 icher” effect, whose extent may play a general role in the determination of
  condensate size distributions.\n
X-ALT-DESC;FMTTYPE=text/html:<p>Abstract: An emerging mechanism for intracellular organization is biomol
 ecular phase separation into condensates of proteins and nucleic acids. How
 ever, the physical processes that govern the distribution of condensate siz
 es remain unclear. We utilize a combination of experimental synthetic and n
 ative condensates and simulations to probe the underlying coarsening mechan
 isms determining condensate size. Distributions range from exponential to p
 ower-law, reflecting the relative rates of nucleation and coalescence kinet
 ics. We succinctly account for these differences by indentifying a “rich ge
 t richer” effect, whose extent may play a general role in the determination
  of condensate size distributions.</p>
CONTACT:Ned Wingreen - Princeton University
DTSTAMP:20260828T094306
DTSTART;TZID=America/New_York:20220309T104500
DTEND;TZID=America/New_York:20220309T234500
SEQUENCE:0
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