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UID:e3f09736d16b5e9019e0f1e53dfa70ad
CATEGORIES:Mathematical Physics Seminar
CREATED:20260428T133821
SUMMARY:Webinar: Ned Wingreen - Collective dynamics in B cell affinity maturation
LOCATION:zoom
DESCRIPTION:<p style="text-align: center;"><strong>Ned Wingreen – Princeton University&
 nbsp;</strong></p><p style="text-align: center;"><strong>Wednesday,&nbsp;Ma
 y 27,&nbsp;2026</strong></p><p style="text-align: center;"><strong>Zoom ope
 ns: 10:30AM EDT</strong></p><p style="text-align: center;"><strong>Seminar 
 begins: 10:45AM EDT</strong></p><p style="text-align: center;"><strong>&nbs
 p;Collective dynamics in B cell affinity maturation</strong></p><p>In the h
 umoral immune response, B cells that produce high-affinity antibodies are g
 enerated through a Darwinian evolutionary process called affinity maturatio
 n. Affinity maturation, which takes place in germinal centers (GC), is driv
 en by cycles of selection (mediated by T cells), division, and hypermutatio
 n of B cells. Recently, it was found that the T cells themselves also exhib
 it dynamic behavior throughout the course of the GC reaction, undergoing af
 finity-dependent proliferation. A model suggests that this reciprocal stimu
 lation enforces a robust “homeostatic” regulation of the relative number of
  B cells and T cells in the GC, leading to a constant ratio of GC lymphocyt
 es. But the model also&nbsp;points to a problem: the high mutation rate of 
 GC B cells can lead to “backsliding” of affinity. The proposed solution – a
  fitness-dependent mutation rate – has been experimentally verified, and ha
 s implications beyond B cell affinity maturation.</p>
DTSTAMP:20260826T173108
DTSTART;TZID=America/New_York:20260527T104500
DTEND;TZID=America/New_York:20260527T120000
SEQUENCE:0
TRANSP:OPAQUE
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